I just found TweetDeck

I just found TweetDeck - Jebus I didn’t know what I was missing. I spent all day researching. It is amazingly simple to use and set up groups of followers and people you are following. Very powerful search tool too!

From the TweetDeck website:

TweetDeck is an Adobe Air desktop application that is currently in public beta. It aims to evolve the existing functionality of Twitter by taking an abundance of information i.e twitter feeds, and breaking it down into more manageable bite sized pieces.

TweetDeck enables users to split their main feed (All Tweets) into topic or group specific columns allowing a broader overview of tweets. The default columns can contain All Tweets from your timeline, @replies directed to you and direct messages. The GROUP, SEARCH and REPLIES buttons then allow the user to make up additional columns populated from the live tweet information. Once created these additional columns will automatically update allowing the user to keep track of a twitter threads far easier.